BLEOMYCIN A5 HYDROCHLORIDE
- Product Name
- BLEOMYCIN A5 HYDROCHLORIDE
- CAS No.
- 55658-47-4
- Chemical Name
- BLEOMYCIN A5 HYDROCHLORIDE
- Synonyms
- BLEOCIN(TM);Bleomycin A5 HCl Salt;BLEOCIN(TM) ANTIBIOTIC;Bleomycin A5 Hydrochlorid;Bleomycin A5 Hydrochloride;Bleomycin A5 Hydrochloride Salt;BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP;BLEOCIN(TM), STREPTOMYCES VERTICILLUS;BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%;N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
- CBNumber
- CB9762129
- Molecular Formula
- C57H90ClN19O21S2
- Formula Weight
- 1477.03
- MOL File
- 55658-47-4.mol
BLEOMYCIN A5 HYDROCHLORIDE Property
- Melting point:
- >185°C (dec.)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Pale Yellow
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 19692
- Product name
- Bleomycin A5 (hydrochloride)
- Purity
- ≥85%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 19692
- Product name
- Bleomycin A5 (hydrochloride)
- Purity
- ≥85%
- Packaging
- 5mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- 19692
- Product name
- Bleomycin A5 (hydrochloride)
- Purity
- ≥85%
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 19692
- Product name
- Bleomycin A5 (hydrochloride)
- Purity
- ≥85%
- Packaging
- 25mg
- Price
- $438
- Updated
- 2021/12/16
- Product number
- 257225
- Product name
- Bleomycin A5 hydrochloride
- Packaging
- 10mg
- Price
- $406
- Updated
- 2021/12/16
BLEOMYCIN A5 HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.
Biological Activity
bleomycin a5 is an anticancer chemotherapeutic that binds dna and induces dna cleavage and strand breaks, it is highly toxic. additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. bleomycin may also inhibit thioredoxin reductase.
in vitro
the ic50 of blm alone to the cells was about 2.63 μg/ml. the ic50 of blm was decreased to 1/3.8 and 1/9.5 of 2.63 μg/ml when used in combination with 2.63 μg/ml and 5 μg/ml w-131 [1]. bleomycin a5 induced the activation of a jnk pathway in a dose-dependent manner. after 24h treatment, bleomycin a5 induced dramatic cell death. dapi nuclear staining assay revealed that pd98059 (10 μm) markedly enhanced bleomycin a5-induced apoptosis [2].
in vivo
in the rats, bleomycin a5 induced pulmonary inflammation and fibrosis, increased the levels of malondialdehyde and tumour necrosis factor-α and enhanced accumulation of collagen in the lungs. rolipram administration significantly attenuated these effects [3].
References
[1]. zhang h q, he n g, xue s b. effect of bleomycin a5 with calmodulin inhibitor on the proliferation of s-180 cells in vitro[j]. zhongguo yao li xue bao= acta pharmacologica sinica, 1990, 11(5): 470-473.
[2]. yang l c, yang s h, tai k w, et al. mek inhibition enhances bleomycin a5‐induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities[j]. journal of oral pathology & medicine, 2004, 33(1): 37-45.
[3]. pan j b, hou y h, zhang g j. rolipram attenuates bleomycin a5‐induced pulmonary fibrosis in rats[j]. respirology, 2009, 14(7): 975-982.
BLEOMYCIN A5 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BLEOMYCIN A5 HYDROCHLORIDE Suppliers
View Lastest Price from BLEOMYCIN A5 HYDROCHLORIDE manufacturers
- Product
- BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01
- Product
- BleoMycin A5 Hydrochloride 55658-47-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30
- Product
- BLEOMYCIN A5 HYDROCHLORIDE 55658-47-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23